TRANSLATIONAL PHYSIOLOGY Higher urine desmosine levels are associated with mortality in patients with acute lung injury
نویسندگان
چکیده
Dana E. McClintock, Barry Starcher, Mark D. Eisner, B. Taylor Thompson, Doug L. Hayden, Gwynne D. Church, Michael A. Matthay, and the National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network Cardiovascular Research Institute and Division of Occupational and Environmental Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California; University of Texas Health Center at Tyler, Department of Biochemistry, Tyler, Texas; Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, and Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts
منابع مشابه
Higher urine desmosine levels are associated with mortality in patients with acute lung injury.
Desmosine is a stable breakdown product of elastin that can be reliably measured in urine samples. We tested the hypothesis that higher baseline urine desmosine would be associated with higher mortality in 579 of 861 patients included in the recent Acute Respiratory Distress Syndrome Network trial of lower tidal volume ventilation (1). We also correlated urine desmosine levels with indexes of d...
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